I've been playing around with my system lately. I had it clocked at 2.2GHz with the memory at 220MHz. I wanted to see how far I could go and ended up with the processor at 2.5GHz (10x250). However, my memory won't really go past 225 so I had to use the 5/6 divider leaving my memory at 208MHz.
According to most of what I have read, the extra latency created by using the divider doesn't create any slowdowns. I have not noticed it in any other games. Then tonight I loaded up RTW after not having played in a couple weeks. The game load times are significantly longer.
I dropped it back down to 2.2 and they picked back up.
Has anyone else noticed this?